Which adverse effect is classically associated with MAOIs?

Which adverse effect is classically associated with MAOIs?

• A. Hyperglycemia
• B. Sedation
• C. Hypotension
• D. Lethal hypertensive crisis

Answer: (D)

Monoamine oxidase inhibitors block the breakdown of monoamines like tyramine. When tyramine-containing foods are consumed, tyramine is absorbed and causes a large release of norepinephrine, leading to sudden, extreme vasoconstriction and a drastic rise in blood pressure. This can trigger a hypertensive crisis that can be life-threatening, which is the characteristic risk associated with MAOIs. That’s why this adverse effect is highlighted as a classic danger with these drugs. Other options don’t fit this defining risk: hyperglycemia isn’t a typical MAOI issue, and while some patients may experience sedation or hypotension, they don’t represent the hallmark, potentially lethal event.

Monoamine oxidase inhibitors block the breakdown of monoamines like tyramine. When tyramine-containing foods are consumed, tyramine is absorbed and causes a large release of norepinephrine, leading to sudden, extreme vasoconstriction and a drastic rise in blood pressure. This can trigger a hypertensive crisis that can be life-threatening, which is the characteristic risk associated with MAOIs. That’s why this adverse effect is highlighted as a classic danger with these drugs. Other options don’t fit this defining risk: hyperglycemia isn’t a typical MAOI issue, and while some patients may experience sedation or hypotension, they don’t represent the hallmark, potentially lethal event.